Coleus root contains a chemical called forskolin. Colforsin has a higher affinity for type 5 AC (myocardial AC), does not appear to cross the blood-brain barrier, and exerts a longer duration of action than forskolin. Forskolina, ou forscolina, cujo nome deriva do anterior nome binomial da espécie, Coleus forskohlii, é um importante constituinte de Plectranthus barbatus, a única fonte comercialmente significativa daquele … This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Forskolin is available under the following different brand names: coleus forskohlii, colforsin, makandi, maohouqiaoruihua, and pashanabhedi. Research reveals no clinical data regarding the use of forskolin for antithrombotic effects. Growing Coleus from Seeds Start the seeds in early spring. In 1962, J.K. Morton noted that fused stamens were more widespread than previously thought, and accordingly merged Coleus into Plectranthus, while maintaining Solenostemon and some other genera as distinct. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Coleus blumei, Plectranthus scutellarioides), which is popular as a garden plant for its brightly colored foliage. Some of the species within the genus are difficult to distinguish, leading to unclear taxonomy. [2], A preliminary study of the tribe Ocimeae in 2004 showed that the subtribe Plectranthinae was monophyletic, with two main clades: one containing the type species of Coleus and including Solenostemon, the other containing the type species of Plectranthus along with some other genera, so that Plectranthus when broadly defined was not monophyletic. Scientific Name(s): Coleus barbatus, Coleus coerulescens, Coleus forskohlii auct., Plectranthus barbatus Andrews, Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus grandis, Plectranthus kilimandschariCommon Name(s): Adel Inj, Asthma X-5, Ele-max, Forskolin, ForsLean, GlucoLean, HL-362, Indian coleus, Interex, Makandi, Mao hou qiao rui hua, Meta-Burn EF, NKH477, Pashanabhedi. The Plant List, entry for Solenostemon, retrieved June 12, 2015 1. [1] Species include:[2], https://en.wikipedia.org/w/index.php?title=Coleus&oldid=984532807, Articles containing potentially dated statements from July 2020, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License, This page was last edited on 20 October 2020, at 16:02. Coleus Forskohlii or Plectranthus barbatus is a tropical perennial plant from the mint family. Approximately 70 diterpenoids have been described in the leaves, roots, and whole plant, with forskolin (also known as coleonol) being one of the most active compounds.Alasbahi 2010, Because forskolin has been actively pursued as a drug development lead, many analytical chemistry studies exist, and commercially available preparations can be standardized by forskolin content.Alasbahi 2010 Tissue culture methods for forskolin production have also been successfully explored because the relatively modest content of forskolin in the plant has limited its development as a drug.Mersinger 1988, Mukherjee 2000. Medically reviewed by Drugs.com. Equilabium was segregated from Plectranthus, after phylogenetic studies supported its recognition as a phylogenetically distinct genus. Clinical trial data are generally lacking. Clustered purple-blue flowers appear from fall to late spring.PLANTS 2007, Lukhoba 2006, Alasbahi 2010, This species and other related species have been used extensively in many traditional medical systems, including those of Brazil, eastern, and central Africa, as well as India and other Asian countries. A colforsin preparation (Adehl) is approved for use in Japan, and limited studies have been conducted in cardiac surgery, heart failure, and cerebral vasospasm.Alasbahi 2010, Kikura 2004, Hayashida 2001, Suzuki 2006, The use of forskolin in studies involving the CNS is largely related to elucidating the role of cAMP in depression and other cellular processes.Cohen 2004, Gobert 2008, Seo 2009, Radiolabeled forskolin was shown to bind to rat brain membranes in a saturable and specific manner.Seamon 1984 Forskolin demonstrated potent antidepressant activity in a rat forced swimming modelMaeda 1997 and prevented induced seizures in mice.Alasbahi 2010, Clinical trials are lacking; however, case studies using intravenous infusions of forskolin demonstrated a transient elevation in mood in some depressed and schizophrenic patients.Alasbahi 2010, Stimulation of the release of pancreatic insulin and glucagon by forskolin has been demonstrated in vitro.Alasbahi 2010 Influence of forskolin on glucose transport and the action of insulin in skeletal muscle has also been described.Niu 2003, Richmond 2009, Ding 2003 Clinical trials are lacking; however, studies in normal and diabetic rats have shown increases in blood glucose and serum insulin.Alasbahi 2010, Due to its vasodilating properties, forskolin and analogs have been proposed for intercavernosal treatment of erectile dysfunction; however, only small clinical studies have been reported.Drewes 2003, Mulhall 1997 An in vitro study demonstrated increased bovine and human sperm motility with forskolin.Liu 2003, Animal studies have shown that forskolin promotes gastric and pancreatic acid secretion, as well as relaxes intestinal smooth muscle.Alasbahi 2010, Forskolin has been shown to influence cellular immune responses in vitro and in animal experiments.Alasbahi 2010, A double-blind, randomized, placebo-controlled trial conducted in 41 overweight or obese participants evaluated the effect of C. forskohlii extract on appetite hormones and insulin sensitivity. Coleus Herb Claims* C. forskohlii is claimed to support healthy heart, lung, gastrointestinal and immune function, as well as help hypertension (high blood pressure), asthma, … Forskolin derivatives have been developed for use in cardiovascular conditions. This information should not be used to decide whether or not to take this product. Adverse events were not reported.Huerta 2010, González-Sánchez 2006 Colforsin has also been evaluated as a bronchodilator in a limited number of studies.Wajima 2002, Wajima 2003, Bauer 1993, Studies in animals have shown various effects of forskolin, including induction of melatonin production in the pineal glands, increased melanin in hair follicles leading to an increase in pigmentation, increased hair growth, and a protective effect against ultraviolet B light (UBV)-induced apoptosis.Alasbahi 2010, Chen 2009, Lekmine 2008, Passeron 2009, Case reports exist showing improvement of psoriatic symptoms and a decrease in erythema in patients with hyperplastic skin disorders.Alasbahi 2010, Oral forskolin has been studied using 10 mg daily over 2 to 6 months.Huerta 2010, González-Sánchez 2006, 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied.Godard 2005, Henderson 2005, Information regarding safety and efficacy in pregnancy and lactation is lacking. As a consequence of gluconeogenesis, interference with medicines used in diabetes may be expected.Alasbahi 2010, Forskolin-like substances have been identified in renal cyst fluid; therefore, forskolin should be avoided in patients with polycystic kidney disease.Putnam 2007, Large doses in mice have been reported to have a depressant action on the CNS, and perianal dermatitis has been reported with the use of whole plant extracts.Lukhoba 2006, Alasbahi 2010 Clinical trial data are generally lacking; however, a clinical trial found no changes in various metabolic markers or laboratory indices, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005 Adverse events reported with the use of colforsin (a forskolin derivative) include tachycardia and arrhythmias.Alasbahi 2010, Hayashida 2001, Toxicology information is limited. The plant is native to subtropical and tropical regions of India and East Africa, grows to a height of 60 cm, and has large, soft leaves. For best results, plant the seeds indoors, … Coleus forskohlii is the only known natural source of the unique adenylate cyclase activating phytonutrient, forskolin3. The root has been used in traditional Indian medicine for centuries to treat heart disease, lung … Used for allergic conditions such as asthma and eczema, … coleus forskohlii coleus forskohlii I still don’t know how to pronounce it, but it’s a super amazing ayurvedic herb in the mint/lavender family. Coleus is a genus of annual or perennial herbs or shrubs, sometimes succulent, sometimes with a fleshy or tuberous rootstock, found in the Old World tropics and subtropics. Forskolin exhibits cardiovascular properties and may have additive effects with anticoagulants, antihypertensives, and vasodilators. This product may be unsafe when used before surgery or other medical procedures. This information relates to an herbal, vitamin, mineral or other dietary supplement. barbatus）とはインドやネパールに自生するシソ科の植物でインドの伝統医学・アーユルヴェーダにおいて用い … 1. Experimental studies on various cancer cell lines have shown synergistic effects of forskolin in upregulating cellular responses.Lekmine 2008, Watanabe 2004, Watanabe 2005, Tong 2004, Li 2006, Kim 2004 A protective effect against ionizing radiationSolovjeva 2009 and UBV-induced apoptosisPasseron 2009 has been shown in vitro. I'm assuming that … [4] Most sources followed Morton in submerging Coleus; some kept Solenostemon distinct, although others submerged it into Plectranthus along with Coleus. In India, the plant is cultivated for use in pickles.Alasbahi 2010, Insel 2003, Alasbahi 2010, The main constituents of P. barbatus are the diterpenoids and essential oil. Outside this plant needs total shade or only the most mild morning sunlight.[3]. Plectranthus barbatus, also known by the synonym Coleus forskohlii is a tropical perennial plant related to the typical coleus species. mô tả khoa học đầu tiên năm 1897. It is composed of about 150 species under the Mint family of plants … Loài này được (Willd.) Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine). Obesity/Metabolic syndrome: 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied. It grows in tropical regions of Asia such as Nepal, India, and Thailand. Adenylate cyclase is the enzyme involved in the production of Cyclic Adenosine Monophosphate (cAMP), a significant biochemical agent in metabolic processes. Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine).. Today, Coleus forskohlii is used as a fat burning supplement.
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